A circuit modulator

Copper is an endogenous modulator of neural circuit spontaneous activity.

For reasons that remain insufficiently understood, the brain requires among the highest levels of metals in the body for normal function. The traditional paradigm for this organ and others is that fluxes of alkali and alkaline earth metals are required for signaling, but transition metals are maintained in static, tightly bound reservoirs for metabolism and protection against oxidative stress. ...

Thalamic Circuit Diversity: Modulation of the Driver/Modulator Framework

The idea that dorsal thalamic inputs can be divided into "drivers", which provide the primary excitatory drive for the relay of information to cortex, and "modulators", which alter the gain of signal transmission, has provided a valuable organizing principle for the study of thalamic function. This view further promoted the identification of "first order" and "higher order" thalamic nuclei, bas...

Design and Realization of an Improved De-Q-ing Circuit for Regulation of Modulator Output Pulse Amplitudes in a Radar Transmitter

Design and Realization of an Improved De-Q-ing Circuit for Regulation of Modulator Output Pulse Amplitudes in a Radar Transmitter

Parallel regulation of a modulator-activated current via distinct dynamics underlies comodulation of motor circuit output.

The cellular mechanisms underlying comodulation of neuronal networks are not elucidated in most systems. We are addressing this issue by determining the mechanism by which a peptide hormone, crustacean cardioactive peptide (CCAP), modulates the biphasic (protraction/retraction) gastric mill (chewing) rhythm driven by the projection neuron MCN1 in the crab stomatogastric ganglion. MCN1 activates...